Morphological and Laboratory improvement of Cisplatin - induced azoospermia using Adipose derived mesenchymal stem cells in a Rabbit model

The testes are highly susceptible to the adverse effects of chemotherapy and radiation at all stages life. Exposure these threats mainly occurs during cancer treatment as an occupational hazard in centers. present study investigated regenerative ability adipose-derived mesenchymal stem cells (ADMSCs) against cisplatin on structure function testes. New Zealand white male rabbits (N = 15) were divided into three groups five: a negative control group (no treatment), (single dose each testis), with ADMSCs (cisplatin was injected followed by ADMSC injection days later). On day 45 post-treatment, serum testosterone levels evaluated, epididymis collected for histology, epididymal sperm analysis. Cisplatin caused damage testicular tissue decreased counts ADMSC-treated displayed moderate count, suitable hormone levels, enhanced morphology. damaged modified pathological changes cisplatin.